Matrix below shows most important differences between these two Phyton in-system device programmer platforms

Feature ChipProg-ISP2 (CPI2-B1 model) ChipProg-ISP (EOL)
Expected life time Released in mid 2016 with projected production for at least the next 10 years. Released in 2005. Discontinued in April of 2017. Support no new devices was stopped. Not recommended for new projects.
Device lists Same for both models by Sep 1, 2016 but then will grow faster for CPI2-B1. New technology supports modern complex MCUs and SoCs, which cannot be supported by ChipProg-ISP. Same for both models by Sep 1, 2016. Support no new devices was stopped.
Stand-alone mode Can work in stand-alone mode, being disconnected from a computer. Not available. Works under external computer control only.
Control interfaces USB2.0 high speed mode and Ethernet 100 Mbit/s. USB2.0 only.
Programming speed Very fast, especially in the stand-alone mode. Pretty slow on SPI memory devices.
Proximity to target Up to 5 m or ~15 ft (actual distance is target specific). Up to 0.3 m or ~1 ft.
On-programmer project storing Stores up to 256 projects on internal SD card. Cannot store projects.
Galvanic isolation Provided with use of Ethernet interfaces. Optionally, the programmer can be equipped with control lines can also be isolated. Not available.
Target device Vcc 1.2 to 5.5V. 1.8 to 5.5V.
Powering targets Vcc (1.2 to 5.5V @ up to 350mА) and Vpp (1.2 to 15V @ up to 80mA) voltages Vcc (1.8 to 5.5V @ up to 80mA) voltage.
Mounting in fixtures Includes a bracket for mounting on a standard DIN rail. Small dongle in a plastic enclosure without self-mounting capability.
Prices The price is the total of hardware plus optional CPI2-ACI and CPI2-D-XXXX device driver library licenses. For example (May 2016), $695 with free basic device driver library; $995 with a single manufacturer’s ARM Cortex driver library. Volume discounts significantly reduce package prices. See the catalog. Flat price of $555 (May 2016) covers the programmer hardware and software that includes device drivers for all supported devices. This price does not cover target-specific cable-adapters and may increase in the future. See the catalog.
All other features are identical or very similar, including project support, script language, graphic user interface (GUI), remote control tools and hooks (DLL, command line, on-the-fly control, etc.), and other software components. This similarity greatly simplifies migrating from the ChipProg-ISP to ChipProg-ISP2 platform and reduces the learning curve.